RxNORM

Breast Cancer

These are the PRIMED Harmonization instructions for breast cancer (BC). We are using the breast cancer definition used by the eMERGE program, with some slight modifications. Follow this document for implementation.
Modifications:
We will only include cis females in the analyses
The standard definition requires controls be age 18+. If the age distribution of cases within a study is much older (e.g. 30+), then studies may filter controls based on age >= the minimum age of identified cases

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Lipids (HDL-C, LDL-C, TG)

This document describes the PRIMED Harmonization algorithms for HDL-C, LDL-C, and TG.
• High density lipoprotein (HDL-C)
• Triglycerides (TG):
o Non-fasting
• Low-density lipoprotein (LDL-C):
o Unadjusted non-fasting
o Adjusted non-fasting
Overall procedure
1. Extract trait measurements using measurement codes and calculations
2. Convert measurement units to expected units, if necessary
3. Apply measurement exclusion criteria
4. Prepare measurements for analysis

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Type 2 Diabetes (T2D)

There are two case algorithms provided for T2D. The first (t2d_dprism_ehr_plus_1) is the preferred case algorithm and includes self-reported T2D information collected from survey. The second (t2d_dprism_ehr_1) is an alternative case algorithm that does NOT include self-reported T2D information collected from survey.
We request harmonization based on the preferred algorithm, but if self-reported T2D survey information is not available, the alternative algorithm is acceptable.

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Final