Peanut Allergy

Food allergy is defined as an immune response that occurs reproducibly to a given food, typically an immunoglobulin E (IgE)-mediated clinical reaction to specific protein epitopes.  Over the last 20-30 years, food allergy has grown into a major public health problem.  Peanut allergy is a common type of food allergy that accounts for a disproportionate number of fatal and near-fatal anaphylactic events amongst all the common food allergens.

A large new GWAS within a pre-existing food allergy cohort recently discovered two specific genetic associations with peanut allergy for the first time.  A single nucleotide polymorphism (SNP) rs9275596, which is intergenic between the HLA-DQB1 and HLA-DQA2 genes, was found to affect DNA methylation, while SNP rs7192 confers a Leu242Val change in the HLA-DRA gene product.

Within Vanderbilt's BioVU and Synthetic Derivative database, our group found a suggestive association that HLA-DQB1*05:02 (p=0.07, OR 1.25) correlated with increased risk of peanut allergy and HLA A*68 (p=0.10, OR 0.70) correlated with decreased risk.

A more large scale study is ongoing.  

***We are making this algorithm available for collaboration.***

Phenotype ID: 
609
Status: 
List on the Collaboration Phenotypes List
Type of Phenotype: 
Data Modalities and Methods Used: 
Authors: 
Hemler JA, Phillips EJ, Mallal SA, Kendall PL
Contact Author: 
 

Suggested Citation

Hemler JA, Phillips EJ, Mallal SA, Kendall PL. Vanderbilt University, Vanderbilt University Medical Center. Peanut Allergy. PheKB; 2016 Available from: https://phekb.org/phenotype/609

PubMed References

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