Disease or Syndrome

Herpes Zoster

Herpes zoster, also known as zoster or shingles, is caused by a virus called varicella zoster virus (VZV). Initial infection with the virus causes chickenpox. After chickenpox resolves the virus continues to resides in certain nerve cells. It may remain latent for many years. It may also re-activate, many years later, and cause shingles which is a painful skin rash. How the virus remains latent in the body is not well understood.

Owner Phenotyping Groups:

eMERGE GHC/University of Washington Group

View Phenotyping Groups:

eMERGE Phenotype WG

Final

HIV

Algorithm for the identification of all patients aged 13 or older with HIV in an electronic health record dataset.

Final

Hypothyroidism

Project Outline: Selection of all Caucasian patients with hypothyroidism without a secondary cause of surgical removal or radiological ablation. The search is designed to eliminate subclinical hypothyroidism (by requiring that patients be on a replacement medication), medication-induced hypothyroidism (e.g., PTU, lithium, or history of amiodarone), and transient causes (e.g., pregnancy or subacute thyroiditis).

Owner Phenotyping Groups:

eMERGE Vanderbilt Group

View Phenotyping Groups:

eMERGE Phenotype WG

Final

Identification of Fibromyalgia Patients in a Rheumatoid Arthritis Cohort

Fibromyalgia has been estimated to affect 12-17% of rheumatoid arthritis patients (1, 2).

This algorithm was created to identify fibromyalgia patients in a population of rheumatoid arthritis patients. The gold standard used for diagnosis of fibromyalgia was that the treating rheumatologist made a clinical diagnosis of fibromyalgia. Rheumatoid arthritis patients were identified by using a previously validated algorithm (3).

Algorithm included the following conditions:

Owner Phenotyping Groups:

Denny’s Group at Vandy

Final

Intellectual Disability

Owner Phenotyping Groups:

eMERGE CHOP Group

View Phenotyping Groups:

eMERGE CHOP Group

eMERGE Phenotype WG

Final

Liver cancer staging project

Hepatocellular carcinoma (HCC), the primary form of liver cancer, is one of the leading cancer-related causes of death worldwide. There are many complex treatment strategies; the populations are heterogeneous, with different genetic, lifestyle, and comorbity differences.

Here we describe the algorithm used to identify HCC liver cancer stages for AJCC, BCLC, and CLIP liver cancer staging systems.

Algorithm:

Step 1) Patient files and laboratories

Final

MidSouth CDRN - Coronary Heart Disease Algorithm

Owner Phenotyping Groups:

PCORI MidSouth CDRN

View Phenotyping Groups:

PCORI CDRN/PPRN

Final

Migraine

Migraine is the most common recurrent headache syndrome in children in which 4-10% of school age children may be affected (1). It is characterized by episodes of headache pain that may be accompanied by nausea, vomiting, and light and sound sensitivity. Migraine occurs at all ages and may even begin in infancy as represented by intermittent colic (1). The genes for familial hemiplegic migraine have been identified.

Owner Phenotyping Groups:

eMERGE CCHMC Group

View Phenotyping Groups:

eMERGE Phenotype WG

Final